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Vitamin E capsules – Evion 400 mg


  • Evion 400Mg
  • Pack Size:30 capsules


Description Evion contains Vitamin E. It is a lipid soluble vitamin. The pharmacological effect is mainly due to its antioxidant properties. 

Indications: Evion soft gelatin capsule are indicated for the therapeutic management of Vitamin E deficiency caused by malabsorption in congenital or hereditary chronic cholestasis Nocturnal muscle cramps, intermittent claudication and fibrocystic breast disease, Vit E supplementation is also found to be beneficial in male infertility. Evion is also indicated as a dietary supplement. in malabsorption syndromes and in those Who are on a diet rich in PUFA. 

Contraindications: Hypersensitivity to Vitamin E, or to any excipients. 

Special warnings and precautions for use: Vitamin E has been reported to increase bleeding tendency in Vitamin-K deficient patients or those taking anticoagulant treatments, it is therefore recommended to monitor the prothrombin time and international normalized ratio (INR) to detect any changes in homeostasis. A possible adjustment of the dose of anticoagulants during and after treatment With Vitamin E suspension 100 mg/ml maybe necessary. Vitamin E has been reported to increase the risk of thrombosis in patients predisposed to this condition. including patients taking This finding has not been confirmed but should be borne in mind when selecting patients for treatment, in particular women taking oral contraceptives containing estrogens. A higher incidence of necrotizing enterocolitis has been noted in lower weight premature infants (less than 1.5kg) treated with vitamin E  

Pregnancy and lactation: Pregnancy: There is no evidence of the safety of high doses of vitamin E in pregnancy nor is there evidence from animal work that it is free from hazard, therefore do not use in pregnancy especially in the first trimester. Breastfeeding: No information is available on excretion in breast milk; therefore, it is advisable not to use during lactation. Effects on ability to drive and use machines: None known.

Use in special populations: Hepatic impairment- caution should be exercised. Renal impairment – caution should be exercised. Breast feeding – use only if potential benefits outweigh the risk. Pregnancy – no evidence of harm in animal studies. Nevertheless, caution should be exercised. 

Side Effects: Side effects are extremely rare after administration of Vitamin E. Relatively large doses of the order of several hundred day have been administered without appearance of any untoward side effects. Asthenia. Headaches, disturbances in serum potassium and sodium concentration. alopecia. pruritis and rash are commonly reported side effects. Diarrhea. intestinal cramps, angular stomatitis. lethargy, muscle weakness and thrombophlebitis have been reported after unusually large doses (in the range of 1,200 mg/ day). These effects known to be reversed after stopping vitamin E administration. Prolonged intake of doses higher than 600 mg may causes reduced serum thyroid hormone levels. 

Drug Interactions: The effect of vitamin E maybe reduced by co-administration of iron preparations. In co-existing vitamin E and vitamin K deficiencies caused by malabsorption as well as upon administration of vitamin K antagonists (e.g.: oral anticoagulants) blood coagulation must be carefully monitored as a pronounced drop in vitamin K has occurred in individual cases. Vitamin E may increase the risk of hemorrhage in patients taking anticoagulants (see section special warnings and precaution). Vitamin E may increase the risk of thrombosis in patients taking (see section special warnings and precaution). Vitamin E may interfere with the action of iron in relieving iron deficiency anemia. Hence, iron preparation should preferably be taken 8- 12 hrs., before or after vitamin E. The antagonist effect of vitamin E on vitamin K is thought to occur at the level of formation. Since very high doses of vitamin E can reinforce the action of anticoagulants, a regular check on the coagulation parameters is indicated in patients receiving concomitant oral anticoagulant therapy. 

Procter & Gamble Health Ltd 


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